semaglutide blood brain barrier promotes angiogenesis and blood–brain repair after traumatic injury via PDGF-BB/PDGFRβ/Ang1/Tie2/VEGF signaling pathway Frontiers | Reconsidering the role

However, in some people, the underlying problem cannot be reversed

While large Ozempic/Wegovy trials dont typically report estrogen/progesterone changes, smaller studies (especially in PCOS) have measured reproductive hormones

For broader context, see GLP-1 And Alcohol

To view or add a comment, sign in This excellent article by Eliav Barr and Ken Getz describes the burdens placed on patients, investigators, and sponsors by unnecessary complexity in study protocols

The requirements include patients at high metabolic or cardiovascular risk with a BMI greater than 27 with prediabetes or established cardiovascular disease, or a BMI over 30 with uncontrolled hypertension despite treatment, advanced kidney disease, or heart failure